![]() Pooled analyses of 199 placebo-controlled clinical trials (mono- and adjunctive therapy) of 11 different AEDs showed that patients randomized to 1 of the AEDs had approximately twice the risk (adjusted RR 1.8, 95% CI:1.2, 2.7) of suicidal thinking or behavior compared to patients taking placebo. Patients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior. If they miss taking the dose after the morning meal, then they should take their usual dose at the usual time that evening after an evening meal.Īntiepileptic drugs (AEDs), including pregabalin, increase the risk of suicidal ideation, thoughts or behavior in patients taking these drugs for any indication. If they miss taking the dose before bedtime, then they should take their usual dose after a morning meal. Missed doses: Advise patients that if they miss taking their dose of extended-release pregabalin after an evening meal, then they should take their usual dose before bedtime after a snack. ![]() When switching from immediate-release to extended-release pregabalin, on the day of the switch, instruct patients to take their morning dose of immediate-release pregabalin as prescribed and initiate extended-release pregabalin therapy after the evening meal. Instruct patients not to take 2 doses at the same time. If it is almost time for the next dose, they should skip the missed dose and take the next dose at their regularly scheduled time. Missed doses: Advise patients that if they miss a dose, then they should take it as soon as they remember. Immediate-release capsules and oral solutionīoth capsules and oral solution may be administered without regard to meals. When discontinuing pregabalin, taper the dose gradually over a minimum of 1 week. For patients receiving the 75 mg once a day regimen: take one supplemental dose of 100 or 150 mg. For patients receiving the 25 to 50 mg once a day regimen: take one supplemental dose of 50 or 75 mg. For patients receiving the 25 mg once a day regimen: take one supplemental dose of 25 or 50 mg. In addition to the daily dose adjustment, a supplemental dose should be given immediately following every 4-hour hemodialysis treatment. For patients undergoing hemodialysis, pregabalin daily dose should be adjusted based on renal function. Each 4 hour hemodialysis session removes 50% to 60% of the amount of drug initially present in the circulation in patients on three times weekly hemodialysis, who were administered pregabalin roughly 24 hours prior to next scheduled dialysis session. Pregabalin is effectively removed by hemodialysis. Use of extended-release tablets is not recommended use immediate-release formulations. Use of the extended-release tablet is not recommended. ![]() Use of the extended-release tablet is not recommended.ĬrCl 15 mL/minute or less: 25 to 75 mg PO once daily. The following recommendations have been made for adults :ĬrCl 60 mL/minute or more: No dose adjustment needed.ĬrCl 30 to 60 mL/minute: 75 to 300 mg/day PO given in 2 or 3 divided doses for immediate-release formulations reduce dose by 50% for extended-release tablets.ĬrCl 15 to 30 mL/minute: Immediate-release formulations: 25 to 150 mg/day PO given in 1 or 2 divided doses. ![]()
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